Nonlinear Phenomena in Complex Systems, 2001, Vol.4, No.3, pp.280-284

NONLINEAR PHENOMENA IN COMPLEX SYSTEMS
An Interdisciplinary Journal

2001, Volume 4, Number 3, pp.280-284

Calcium Oscillations in the Living Cell: Biological Relevance of Multi-compartment Mathematical Models
M. Brumen, A. Fajmut, and M. Marhl

A two store model and a three store model of intracellular calcium oscillations, both based on calcium induced calcium release mechanism (CICR), are presented. The calcium stores considered are endoplasmic reticulum, proteins, and additionally mitochondria. A comparison of predictions of the two models is biologically performed in order to reveal a possible role of mitochondria as a calcium store.
Key words: intracellular calcium oscillations, mathematical modelling, calcium stores, mitochondria

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